Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7850606 | 0.99 | KMT2A (0.40) | KMT2ATP53LMNAHCRTR1HCRTR2 | |
| SCHEMBL7838935 | 0.93 | KMT2A (0.40) | KMT2ATP53LMNAHCRTR1HCRTR2 | |
| Hydrochloric Acid SCHEMBL7856031 | 0.93 | KMT2A (0.40) | KMT2ATP53LMNAHCRTR1HCRTR2 | |
| SCHEMBL7838649 | 0.93 | LMNA (0.41) | KMT2ATP53LMNAHCRTR1HCRTR2 | |
| Hydrochloric Acid SCHEMBL7845209 | 0.92 | LMNA (0.40) | KMT2ATP53LMNAHCRTR1HCRTR2 | |
| SCHEMBL7852047 | 0.91 | KDM4E (0.39) | KMT2ATP53LMNAHCRTR1HCRTR2 | |
| SCHEMBL7854922 | 0.91 | KMT2A (0.42) | KMT2ATP53LMNAHCRTR1HCRTR2 | |
| Hydrochloric Acid SCHEMBL7855697 | 0.90 | LMNA (0.40) | KMT2ATP53LMNAHCRTR1HCRTR2 | |
| Hydrochloric Acid SCHEMBL7843355 | 0.90 | KMT2A (0.42) | KMT2ATP53LMNAHCRTR1HCRTR2 | |
| SCHEMBL8405521 | 0.89 | CCR5 (0.38) | KMT2ATP53LMNAHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129076-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS LHRH ANTAGONISTS | ABBOTT LABORATORIES (US) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000029380-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS LHRH ANTAGONISTS | ABBOTT LABORATORIES (US) | 2000-05-25 | — | — | WO | disclosed |
| US-5981521-A | USEFUL FOR TREATING VARIOUS HORMONE DEPENDENT DISEASES, INCLUDING PROSTATE CANCER, ENDOMETRIOSIS, UTERINE FIBROIDS, PRECOCIOUS PUBERTY, BENIGN PROSTATE HYPERTROPY AND IN VITRO FERTILIZATION | ABBOTT LABORATORIES (US) | 1999-11-09 | — | — | US | disclosed |