Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 10/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 9/20 | 0.39 |
| ▸ | ITGB6 | P18564 | 6/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.38 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.38 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.38 |
| ▸ | ITGA8 | P53708 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6776927 | 0.90 | ITGB3 (0.47) | ITGB3ITGA2BITGAVITGB6ITGB1 | |
| SCHEMBL7345970 | 0.86 | ITGB3 (0.47) | MEN1KMT2AITGB3ITGAVITGB6 | |
| SCHEMBL7823590 | 0.85 | ITGB3 (0.48) | MEN1KMT2AITGB3ITGAVITGB6 | |
| SCHEMBL7341387 | 0.85 | ITGB3 (0.42) | MEN1KMT2AITGB3ITGAVITGB6 | |
| SCHEMBL7824830 | 0.83 | ITGB3 (0.48) | KMT2AITGB3ITGAVITGB6ITGB1 | |
| SCHEMBL7836752 | 0.82 | ITGB3 (0.43) | MEN1KMT2AITGB3ITGAVITGB6 | |
| SCHEMBL7823058 | 0.82 | RAB9A (0.50) | RAB9ANPC1MEN1KMT2AITGB3 | |
| SCHEMBL7843533 | 0.81 | ITGB3 (0.45) | MEN1KMT2AITGB3ITGAVITGB6 | |
| SCHEMBL7834860 | 0.80 | ITGB3 (0.61) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL6780175 | 0.79 | HSD17B10 (0.45) | MEN1KMT2AHSD17B10ITGB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |