Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843536 | 0.86 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL7840875 | 0.83 | PTGS2 (0.67) | PTGS2PTGS1ALOX5 | |
| SCHEMBL7841730 | 0.82 | PTGS2 (0.55) | PTGS2PTGS1ALOX5 | |
| SCHEMBL7842946 | 0.81 | PTGS2 (0.72) | PTGS2PTGS1ALOX5 | |
| SCHEMBL8918758 | 0.81 | PTGS2 (0.48) | PTGS2PTGS1 | |
| SCHEMBL7846132 | 0.80 | PTGS2 (0.53) | PTGS2PTGS1ALOX5 | |
| SCHEMBL7832465 | 0.80 | PTGS2 (0.71) | PTGS2PTGS1ALOX5 | |
| SCHEMBL7834122 | 0.80 | PTGS2 (0.72) | PTGS2PTGS1ALOX5 | |
| SCHEMBL7844098 | 0.80 | PTGS2 (0.72) | PTGS2PTGS1ALOX5 | |
| SCHEMBL7839858 | 0.80 | PTGS2 (0.54) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |