Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.75 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.50 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6513400 | 0.86 | PTGS2 (0.78) | PTGS2MAPK14PTGS1 | |
| SCHEMBL3242265 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL213779 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL30712534 | 0.84 | PTGS2 (0.65) | PTGS2MAPK14PTGS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7843990 | 0.82 | PTGS2 (0.66) | PTGS2MAPK14PTGS1 | |
| SCHEMBL7846640 | 0.82 | PTGS2 (0.62) | PTGS2MAPK14PTGS1ALDH1A1ALOX5 | |
| SCHEMBL6511496 | 0.82 | PTGS2 (0.65) | PTGS2MAPK14PTGS1 | |
| SCHEMBL7844433 | 0.81 | PTGS2 (0.80) | PTGS2MAPK14 | |
| SCHEMBL7844540 | 0.81 | PTGS2 (0.79) | PTGS2MAPK14PTGS1ALDH1A1ALOX5 | |
| SCHEMBL7842256 | 0.81 | PTGS2 (0.79) | PTGS2MAPK14PTGS1ALDH1A1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |