Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.80 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.77 |
| ▸ | CDC7 | O00311 | 2/20 | 0.54 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6503233 | 0.89 | PTGS2 (0.78) | PTGS2MAPK14 | |
| SCHEMBL6508524 | 0.89 | PTGS2 (1.00) | PTGS2MAPK14 | |
| SCHEMBL7841916 | 0.89 | PTGS2 (1.00) | PTGS2MAPK14 | |
| SCHEMBL7843526 | 0.88 | PTGS2 (0.78) | PTGS2MAPK14 | |
| SCHEMBL6503358 | 0.88 | PTGS2 (0.78) | PTGS2MAPK14 | |
| SCHEMBL7832424 | 0.87 | PTGS2 (1.00) | PTGS2MAPK14 | |
| SCHEMBL6280887 | 0.87 | MAPK14 (1.00) | PTGS2MAPK14 | |
| SCHEMBL6504016 | 0.85 | MAPK14 (0.81) | PTGS2MAPK14 | |
| SCHEMBL11456658 | 0.85 | CDC7 (0.67) | PTGS2MAPK14CDC7DBF4CCNE1 | |
| SCHEMBL7843084 | 0.84 | PTGS2 (0.85) | PTGS2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |