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Sugi Predict / Compounds / SCHEMBL7843733

SCHEMBL7843733

SCHEMBL7843733

COc1cc2c(Oc3ccc(N(C(=O)Nc4ccc(F)cc4F)N(C(=O)Nc4ccc(F)cc4F)c4ccc(Oc5ccnc6cc(OCCn7ccnn7)c(OC)cc56)cc4Cl)c(Cl)c3)ccnc2cc1O

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ KDR P35968 12/20 0.58
▸ PDGFRA P16234 7/20 0.54
▸ AXL P30530 4/20 0.54
▸ FGFR2 P21802 3/20 0.54
▸ KIT P10721 1/20 0.54
▸ FLT1 P17948 3/20 0.47
▸ FGFR1 P11362 2/20 0.47
▸ FGFR4 P22455 2/20 0.47
▸ FGFR3 P22607 2/20 0.47
▸ FLT4 P35916 2/20 0.47
▸ MET P08581 3/20 0.45
▸ EGFR P00533 2/20 0.45
▸ AURKB Q96GD4 1/20 0.45
▸ PDGFRB P09619 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7843737 0.90 KDR (0.72) KDRPDGFRAAXLFGFR2KIT
SCHEMBL5207839 0.87 KDR (0.77) KDRPDGFRAAXLFGFR2KIT
SCHEMBL5203739 0.77 KDR (0.88) KDRPDGFRAAXLFGFR2KIT
SCHEMBL5205634 0.77 KDR (0.63) KDRPDGFRAAXLFGFR2KIT
SCHEMBL12411324 0.76 KDR (0.58) KDRPDGFRAAXLFGFR2KIT
SCHEMBL5201653 0.76 KDR (0.60) KDRPDGFRAFGFR2KITFLT1
SCHEMBL5202435 0.75 KDR (0.87) KDRPDGFRAAXLFGFR2KIT
SCHEMBL5206153 0.75 KDR (0.77) KDRPDGFRAAXLFGFR2KIT
SCHEMBL1876666 0.75 KDR (0.86) KDRPDGFRAAXLFGFR2KIT
SCHEMBL5207899 0.75 KDR (0.86) KDRPDGFRAAXLFGFR2KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1153920-A1 QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES KIRIN BEER KABUSHIKI KAISHA (JP) 2001-11-14 — — EP disclosed