Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.72 |
| ▸ | PDGFRA | P16234 | 9/20 | 0.63 |
| ▸ | KIT | P10721 | 2/20 | 0.63 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.63 |
| ▸ | AXL | P30530 | 1/20 | 0.63 |
| ▸ | FLT1 | P17948 | 4/20 | 0.52 |
| ▸ | FLT4 | P35916 | 4/20 | 0.52 |
| ▸ | MET | P08581 | 3/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | STK10 | O94804 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207839 | 0.97 | KDR (0.77) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL7843733 | 0.90 | KDR (0.58) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL5203739 | 0.87 | KDR (0.88) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL5202435 | 0.85 | KDR (0.87) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL5207899 | 0.84 | KDR (0.86) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL5206153 | 0.84 | KDR (0.77) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL5201653 | 0.84 | KDR (0.60) | KDRPDGFRAKITFGFR2FLT1 | |
| SCHEMBL5208170 | 0.84 | KDR (0.84) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL5205634 | 0.83 | KDR (0.63) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL5202104 | 0.83 | KDR (0.75) | KDRPDGFRAKITFGFR2AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153920-A1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES | KIRIN BEER KABUSHIKI KAISHA (JP) | 2001-11-14 | — | — | EP | disclosed |