Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832966 | 0.84 | MEN1 (0.44) | MEN1KMT2ASLC6A4CSF1RGSK3B | |
| SCHEMBL7808827 | 0.84 | L3MBTL1 (0.41) | HTR6MEN1KMT2ASLC6A4L3MBTL1 | |
| SCHEMBL7844479 | 0.81 | HTR6 (0.50) | HTR6SLC6A4 | |
| SCHEMBL7855641 | 0.81 | L3MBTL1 (0.39) | HTR6MEN1KMT2ASLC6A4L3MBTL1 | |
| SCHEMBL6613430 | 0.74 | MEN1 (0.47) | HTR6MEN1KMT2ASLC6A4SLC6A2 | |
| SCHEMBL6672565 | 0.74 | MEN1 (0.47) | HTR6MEN1KMT2ASLC6A4SLC6A2 | |
| SCHEMBL5792377 | 0.71 | SLC6A4 (0.63) | HTR6SLC6A4SLC6A2SLC6A3 | |
| Ethylene SCHEMBL7484426 | 0.69 | SLC6A4 (0.60) | HTR6SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL373751 | 0.69 | HTR6 (0.69) | HTR6SLC6A4 | |
| SCHEMBL31146114 | 0.68 | FASN (0.46) | MEN1KMT2ASLC6A4L3MBTL1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147083-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000040554-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |