Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832423 | 0.94 | PTGS2 (0.59) | PTGS2PTGS1ALDH1A1RXFP1KDM4E | |
| SCHEMBL7846283 | 0.93 | PTGS2 (0.58) | PTGS2PTGS1ALDH1A1RXFP1KDM4E | |
| SCHEMBL7842143 | 0.93 | PTGS2 (0.58) | PTGS2PTGS1ALDH1A1RXFP1KDM4E | |
| SCHEMBL7844537 | 0.92 | PTGS2 (0.56) | PTGS2PTGS1ALDH1A1RXFP1KDM4E | |
| SCHEMBL7842639 | 0.91 | PTGS2 (0.69) | PTGS2PTGS1ALDH1A1RXFP1KDM4E | |
| SCHEMBL7844836 | 0.90 | PTGS2 (0.56) | PTGS2PTGS1ALDH1A1RXFP1KDM4E | |
| SCHEMBL11452546 | 0.88 | PTGS2 (0.73) | PTGS2PTGS1ALDH1A1RXFP1KDM4E | |
| SCHEMBL7846626 | 0.88 | PTGS2 (0.52) | PTGS2PTGS1ALDH1A1RXFP1KDM4E | |
| SCHEMBL7843869 | 0.87 | PTGS2 (0.71) | PTGS2PTGS1ALDH1A1RXFP1KDM4E | |
| SCHEMBL7841912 | 0.87 | PTGS2 (0.81) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |