Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842639 | 0.89 | PTGS2 (0.69) | PTGS2PTGS1RXFP1KDM4EALDH1A1 | |
| SCHEMBL7843817 | 0.87 | PTGS2 (0.67) | PTGS2PTGS1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL7843831 | 0.86 | PTGS2 (0.71) | PTGS2PTGS1MAPK14RXFP1KDM4E | |
| SCHEMBL7844537 | 0.85 | PTGS2 (0.56) | PTGS2PTGS1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL7832878 | 0.84 | PTGS2 (0.69) | PTGS2PTGS1RXFP1KDM4EALDH1A1 | |
| SCHEMBL7832423 | 0.84 | PTGS2 (0.59) | PTGS2PTGS1RXFP1KDM4EALDH1A1 | |
| SCHEMBL7840959 | 0.83 | PTGS2 (1.00) | PTGS2PTGS1MAPK14 | |
| SCHEMBL7846283 | 0.83 | PTGS2 (0.58) | PTGS2PTGS1RXFP1KDM4EALDH1A1 | |
| SCHEMBL7842143 | 0.83 | PTGS2 (0.58) | PTGS2PTGS1RXFP1KDM4EALDH1A1 | |
| SCHEMBL7844836 | 0.81 | PTGS2 (0.56) | PTGS2PTGS1RXFP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |