Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.41 |
| ▸ | APP | P05067 | 4/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR7 | P34969 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841722 | 0.89 | HTR1D (0.45) | SLC6A4IDO1 | |
| SCHEMBL6636763 | 0.82 | DRD2 (0.57) | DRD2SLC6A4ADRA1DAPPHTR2C | |
| Ethylene SCHEMBL7483250 | 0.80 | DRD2 (0.55) | DRD2SLC6A4ADRA1DAPPHTR2C | |
| SCHEMBL7844484 | 0.79 | HTR1D (0.48) | SLC6A4IDO1 | |
| SCHEMBL6637435 | 0.76 | IDO1 (0.58) | SLC6A4IDO1HTR2A | |
| SCHEMBL628780 | 0.75 | HTR2C (0.66) | ADRA1DHTR2CADRB2IDO1HTR2A | |
| SCHEMBL6086905 | 0.74 | IDO1 (0.56) | DRD2SLC6A4ADRA1DIKBKBHTR2C | |
| SCHEMBL5793597 | 0.73 | SLC6A4 (0.56) | DRD2SLC6A4HTR2CIDO1HTR2A | |
| SCHEMBL7808829 | 0.73 | HTR1B (0.43) | SLC6A4IDO1HTR2A | |
| SCHEMBL7842998 | 0.73 | HTR1D (0.45) | SLC6A4IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147083-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000040554-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |