Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 2/20 | 0.37 |
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5339310 | 0.87 | CES2 (0.48) | CYP2C9CYP2C19BRD4CES2CES1 | |
| SCHEMBL7833587 | 0.86 | PLK1 (0.42) | AKR1C3AKR1C2PLK1CYP2C9HSD17B10 | |
| SCHEMBL4988038 | 0.86 | PLK1 (0.42) | AKR1C3AKR1C2AKR1C1PLK1TSHR | |
| SCHEMBL6516239 | 0.86 | PLK1 (0.42) | AKR1C3AKR1C2PLK1CES2CES1 | |
| SCHEMBL7843096 | 0.86 | PLK1 (0.42) | AKR1C3AKR1C2PLK1CES2CES1 | |
| SCHEMBL7508723 | 0.84 | PLK1 (0.41) | AKR1C3AKR1C2PLK1CES2CES1 | |
| SCHEMBL7089429 | 0.84 | PLK1 (0.41) | AKR1C3AKR1C2PLK1CES2CES1 | |
| SCHEMBL7845030 | 0.84 | AKR1C3 (0.46) | AKR1C3AKR1C2AKR1C1PLK1CES2 | |
| SCHEMBL10889643 | 0.84 | CES2 (0.48) | AKR1C3AKR1C2AKR1C1PLK1HSD17B10 | |
| SCHEMBL11753507 | 0.83 | AKR1C3 (0.49) | AKR1C3AKR1C2AKR1C1PLK1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |