Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.41 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.41 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CTSV | O60911 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSH | P09668 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CASP14 | P31944 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | CTSZ | Q9UBR2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7695198 | 0.87 | KCNH2 (0.44) | EGFRIRAK4 | |
| SCHEMBL7695196 | 0.87 | KCNH2 (0.44) | EGFRIRAK4 | |
| SCHEMBL7582382 | 0.80 | EGFR (0.51) | EGFRIRAK4 | |
| SCHEMBL12481653 | 0.75 | MEN1 (0.57) | EGFRERBB3TNNI3KPRKDCLMNA | |
| SCHEMBL7856226 | 0.74 | EGFR (0.52) | EGFRERBB3TNNI3KABL1BCR | |
| SCHEMBL8797830 | 0.73 | PRCP (0.60) | EGFRERBB3TNNI3KPRKDC | |
| SCHEMBL8798474 | 0.73 | PRCP (0.60) | EGFRERBB3TNNI3KPRKDC | |
| SCHEMBL8799789 | 0.73 | EGFR (0.52) | EGFRIRAK4ERBB3TNNI3KPRKDC | |
| SCHEMBL8798286 | 0.73 | EGFR (0.59) | EGFRERBB3TNNI3KABL1LMNA | |
| SCHEMBL7856266 | 0.72 | EGFR (0.40) | EGFRERBB3TNNI3KPRKDCCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163242-A2 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | Boehringer Ingelheim Pharma KG (DE) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055162-A2 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-21 | — | — | WO | disclosed |