Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.60 |
| ▸ | TNNI3K | Q59H18 | 9/20 | 0.56 |
| ▸ | EGFR | P00533 | 8/20 | 0.52 |
| ▸ | PIM1 | P11309 | 2/20 | 0.52 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797830 | 1.00 | PRCP (0.60) | PRCPTNNI3KEGFRPIM1ERBB3 | |
| SCHEMBL8798582 | 0.88 | TNNI3K (0.55) | PRCPTNNI3KEGFRPIM1S1PR1 | |
| SCHEMBL8798586 | 0.88 | TNNI3K (0.55) | PRCPTNNI3KEGFRPIM1S1PR1 | |
| SCHEMBL8799768 | 0.87 | TNNI3K (0.56) | PRCPTNNI3KEGFRPIM1ERBB3 | |
| SCHEMBL8799771 | 0.87 | TNNI3K (0.56) | PRCPTNNI3KEGFRPIM1ERBB3 | |
| SCHEMBL8801574 | 0.84 | PRCP (0.49) | PRCPTNNI3KEGFRPIM1S1PR1 | |
| SCHEMBL8799789 | 0.82 | EGFR (0.52) | PRCPTNNI3KEGFRERBB3STK3 | |
| SCHEMBL12481653 | 0.82 | MEN1 (0.57) | TNNI3KEGFRERBB3S1PR1PRKDC | |
| SCHEMBL8798286 | 0.82 | EGFR (0.59) | PRCPTNNI3KEGFRPIM1ERBB3 | |
| SCHEMBL8319701 | 0.77 | EGFR (0.56) | EGFRPIM1MAP4K4CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |