Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 10/20 | 0.66 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CA9 | Q16790 | 3/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.52 |
| ▸ | RORB | Q92753 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843108 | 1.00 | RORC (0.66) | RORCPI4KBCA12CA1CA2 | |
| SCHEMBL7843818 | 0.90 | RORC (0.68) | RORCPI4KBADORA2AADORA1PTGS2 | |
| SCHEMBL7846410 | 0.90 | RORC (0.68) | RORCPI4KBADORA2AADORA1PTGS2 | |
| SCHEMBL7843934 | 0.85 | SMN1; SMN2 (0.58) | ADORA2AADORA1PTGS2PTGS1 | |
| SCHEMBL7832857 | 0.85 | SMN1; SMN2 (0.58) | ADORA2AADORA1PTGS2PTGS1 | |
| SCHEMBL7841561 | 0.83 | PTGS2 (0.71) | CA12CA1CA2CA9PTGS2 | |
| SCHEMBL2753572 | 0.82 | RORC (0.74) | RORCADORA2AADORA1PTGS2RORB | |
| SCHEMBL7846567 | 0.82 | RORC (0.57) | RORCPI4KBPTGS2PTGS1 | |
| SCHEMBL7842901 | 0.81 | SMN1; SMN2 (0.56) | CA1CA2PTGS2PTGS1CA7 | |
| SCHEMBL7840997 | 0.81 | SMN1; SMN2 (0.56) | CA1CA2PTGS2PTGS1CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |