Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 7/20 | 0.72 |
| ▸ | DHFR | P00374 | 5/20 | 0.72 |
| ▸ | FOLR1 | P15328 | 5/20 | 0.72 |
| ▸ | SLC19A1 | P41440 | 5/20 | 0.72 |
| ▸ | SLC46A1 | Q96NT5 | 5/20 | 0.72 |
| ▸ | GART | P22102 | 3/20 | 0.72 |
| ▸ | ATIC | P31939 | 2/20 | 0.72 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.72 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.72 |
| ▸ | FRK | P42685 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844327 | 1.00 | TYMS (0.72) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL15078818 | 1.00 | TYMS (0.72) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL7847673 | 0.95 | FOLR1 (0.65) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL7847672 | 0.95 | FOLR1 (0.65) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL17918514 | 0.94 | TYMS (0.69) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL28515867 | 0.92 | TYMS (0.62) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL208257 | 0.92 | TYMS (0.62) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL12238847 | 0.91 | TYMS (0.63) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL8855175 | 0.91 | TYMS (0.73) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL8855178 | 0.91 | TYMS (0.73) | TYMSDHFRFOLR1SLC19A1SLC46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105396-A1 | PROCESS FOR THE PREPARATION OF PYRROLO[2,3-D]PYRIMIDINES | The Trustees of Princeton University (US) | 2001-06-13 | — | — | EP | disclosed |
| US-6066732-A | Process for the preparation of pyrrolo[2,3-d]pyrimidines | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2000-05-23 | — | — | US | disclosed |
| WO-2000011004-A1 | PROCESS FOR THE PREPARATION OF PYRROLO[2,3-D]PYRIMIDINES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2000-03-02 | — | — | WO | disclosed |