Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 12/20 | 0.73 |
| ▸ | FOLR1 | P15328 | 5/20 | 0.73 |
| ▸ | SLC19A1 | P41440 | 5/20 | 0.73 |
| ▸ | SLC46A1 | Q96NT5 | 5/20 | 0.73 |
| ▸ | DHFR | P00374 | 4/20 | 0.73 |
| ▸ | GART | P22102 | 2/20 | 0.73 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.73 |
| ▸ | ATIC | P31939 | 1/20 | 0.73 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.73 |
| ▸ | FRK | P42685 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8855178 | 1.00 | TYMS (0.73) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL15078816 | 0.97 | TYMS (0.69) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL15078869 | 0.97 | TYMS (0.69) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL15078861 | 0.93 | GART (0.84) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL15078817 | 0.93 | GART (0.84) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL7844327 | 0.91 | TYMS (0.72) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL7844331 | 0.91 | TYMS (0.72) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL15078818 | 0.91 | TYMS (0.72) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL13448780 | 0.89 | TYMS (0.67) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL19623246 | 0.88 | TYMS (0.56) | TYMSFOLR1SLC19A1SLC46A1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150259348-A1 | PROCESS FOR PREPARING PEMETREXED DI POTASSIUM AND ITS HYDRATES | SHILPA MEDICARE LIMITED (IN) | 2015-09-17 | — | — | US | disclosed |
| US-20130165654-A1 | PROCESSES FOR PREPARING PEMETREXED | DR. REDDY'S LABORATORIES, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20110201631-A1 | PHARMACEUTICAL FORMULATIONS COMPRISING PEMETREXED | DR. REDDY'S LABORATORIES LTD. (IN) | 2011-08-18 | — | — | US | disclosed |
| CN-1038415-C | Process for preparing 5-substituted pyrrolo-{2,3-D} pyrimidines | LILLY CO ELI (US) | 1998-05-20 | — | — | CN | disclosed |
| US-5663339-A | Process for preparing 5-substituted pyrrolo-[2,3-D] pyrimidines | ELI LILLY AND COMPANY (US) | 1997-09-02 | — | — | US | disclosed |
| US-5644058-A | Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines | ELI LILLY AND COMPANY (US) | 1997-07-01 | — | — | US | disclosed |
| US-5612482-A | Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines | ELI LILLY AND COMPANY (US) | 1997-03-18 | — | — | US | disclosed |
| US-5416211-A | Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines | ELI LILLY AND COMPANY (US) | 1995-05-16 | — | — | US | disclosed |
| CN-1087910-A | The preparation method of pyrrolo-[2, the 3-d] pyrimidine that 5-replaces | LILLY CO ELI (US) | 1994-06-15 | — | — | CN | disclosed |
| EP-0589720-A2 | Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines | ELI LILLY AND COMPANY (US) | 1994-03-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201631-A1 | PHARMACEUTICAL FORMULATIONS COMPRISING PEMETREXED | TYMP, TYMS, MTHFD1 | TYMS 2/4885FOLR1 18/4885SLC19A1 37/4885 |
| US-20150259348-A1 | PROCESS FOR PREPARING PEMETREXED DI POTASSIUM AND ITS HYDRATES | DPYD, KCNK5, KCNJ11 | TYMS 4/4885FOLR1 235/4885SLC19A1 225/4885 |
| US-20130165654-A1 | PROCESSES FOR PREPARING PEMETREXED | TYMP, TYMS, DPYD | TYMS 2/4885FOLR1 62/4885SLC19A1 117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.