Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 7/20 | 0.62 |
| ▸ | DHFR | P00374 | 5/20 | 0.61 |
| ▸ | FOLR1 | P15328 | 5/20 | 0.61 |
| ▸ | SLC19A1 | P41440 | 5/20 | 0.61 |
| ▸ | SLC46A1 | Q96NT5 | 5/20 | 0.61 |
| ▸ | GART | P22102 | 3/20 | 0.61 |
| ▸ | ATIC | P31939 | 2/20 | 0.61 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.61 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.61 |
| ▸ | FRK | P42685 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28515867 | 1.00 | TYMS (0.62) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL7844331 | 0.92 | TYMS (0.72) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL15078818 | 0.92 | TYMS (0.72) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL7844327 | 0.92 | TYMS (0.72) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL207059 | 0.91 | TYMS (0.50) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL29384389 | 0.90 | TYMS (0.49) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL28690364 | 0.90 | TYMS (0.49) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL27910140 | 0.89 | TYMS (0.60) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL7847672 | 0.87 | FOLR1 (0.65) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL7847673 | 0.87 | FOLR1 (0.65) | TYMSDHFRFOLR1SLC19A1SLC46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112442038-B | Industrial preparation method of pemetrexed disodium | 德州德药制药有限公司 | 2022-09-02 | — | — | CN | claimed |
| CN-112174970-B | Method for preparing pemetrexed disodium with high yield | 德州德药制药有限公司 | 2022-06-07 | — | — | CN | claimed |
| EP-2797920-B1 | ONE POT PROCESS FOR PREPARING PEMETREXED DISODIUM | KOCAK FARMA ILAC VE KIMYA SAN A S (TR) | 2016-02-24 | — | — | EP | claimed |
| US-8952153-B2 | One pot process for preparing pemetrexed disodium | KOCAK FARMA ILAC VE KIMYA SANAYI A.S. (TR) | 2015-02-10 | — | — | US | claimed |
| US-20140309420-A1 | One pot process for preparing pemetrexed disodium | KOCAK FARMA ILAC VE KIMYA SANAYI A.S. (TR) | 2014-10-16 | — | — | US | claimed |
| CN-112442038-B | Industrial preparation method of pemetrexed disodium | 德州德药制药有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-112174970-B | Method for preparing pemetrexed disodium with high yield | 德州德药制药有限公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-110305134-B | Pemetrexed disodium intermediate and preparation method thereof | 鲁南制药集团股份有限公司 | 2022-02-22 | — | — | CN | disclosed |
| CN-110305135-B | Pemetrexed disodium intermediate and preparation method thereof | 鲁南制药集团股份有限公司 | 2022-02-22 | — | — | CN | disclosed |
| US-9718829-B2 | Crystalline forms of pemetrexed diacid and processes for the preparation thereof | SICOR INC. (US) | 2017-08-01 | — | — | US | disclosed |
| US-20170129900-A1 | Crystalline Forms Of Pemetrexed Diacid And Processes For The Preparation Thereof | ASSIA CHEMICAL INDUSTRIES LTD. (IL) | 2017-05-11 | — | — | US | disclosed |
| US-9562050-B2 | Crystalline forms of pemetrexed diacid and processes for the preparation thereof | SICOR, INC. (US) | 2017-02-07 | — | — | US | disclosed |
| WO-2008021410-A2 | HIGHLY PURE PEMETREXED DIACID AND PROCESSES FOR THE PREPARATION THEREOF | SICOR INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| US-7138521-B2 | Crystalline of N-[4-[2-(2-Amino-4,7-dihydro-4oxo-3H-pyrrolo[2,3-D]pyrimidin-5-YL)ethyl]benzoyl]-L-glutamic acid and process therefor | ELI LILLY AND COMPANY (US) | 2006-11-21 | — | — | US | disclosed |
| US-6995185-B2 | Δ1-pyrrolines used as pesticides | BAYER CROPSCIENCE AG (DE) | 2006-02-07 | — | — | US | disclosed |
| US-20040068122-A1 | Delta1-pyrrolines used as pesticides | BAYER CROPSCIENCE AG (DE) | 2004-04-08 | — | — | US | disclosed |
| US-20030216416-A1 | Novel crystalline of n-[4-[2-(2-amino-4,7-dihydro-4oxo-3h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and process therefor | ELI LILLY AND COMPANY | 2003-11-20 | — | — | US | disclosed |
| EP-1259513-B1 | A NOVEL CRYSTALLINE FORM OF N- 4- 2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO 2,3-d]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID AND PROCESS THEREFOR | LILLY CO ELI (US) | 2003-09-10 | — | — | EP | disclosed |
| EP-1259513-A2 | A NOVEL CRYSTALLINE FORM OF N- 4- 2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO 2,3-d]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID AND PROCESS THEREFOR | ELI LILLY AND COMPANY (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001062760-A2 | A NOVEL CRYSTALLINE FORM OF N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-d]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID AND PROCESS THEREFOR | ELI LILLY AND COMPANY (US) | 2001-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040068122-A1 | Delta1-pyrrolines used as pesticides | DDT, ADRA1D, OPRD1 | TYMS 3761/4885DHFR 1401/4885FOLR1 1036/4885 |
| US-20030216416-A1 | Novel crystalline of n-[4-[2-(2-amino-4,7-dihydro-4oxo-3h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and process therefor | SLC7A11, SLC7A1, DHFR | TYMS 119/4885DHFR 3/4885FOLR1 76/4885 |
| US-20170129900-A1 | Crystalline Forms Of Pemetrexed Diacid And Processes For The Preparation Thereof | DCTD, DPYD, DHFR | TYMS 7/4885DHFR 3/4885FOLR1 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.