Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 16/20 | 0.58 |
| ▸ | EDNRB | P24530 | 8/20 | 0.54 |
| ▸ | DHPS | P49366 | 3/20 | 0.54 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.54 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844466 | 1.00 | EDNRA (0.58) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL7840308 | 0.92 | EDNRA (0.47) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL7840305 | 0.92 | EDNRA (0.47) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL7840808 | 0.90 | EDNRA (0.55) | EDNRAEDNRB | |
| SCHEMBL7840810 | 0.90 | EDNRA (0.55) | EDNRAEDNRB | |
| SCHEMBL7842752 | 0.87 | DHPS (0.42) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL7842750 | 0.87 | DHPS (0.42) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL7840430 | 0.85 | EDNRA (0.74) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL795168 | 0.85 | EDNRA (0.74) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| Potassium SCHEMBL7842390 | 0.84 | EDNRA (0.73) | EDNRAEDNRBDHPSABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882719-B1 | ARYLETHENESULFONAMIDE DERIVATIVES AND DRUG COMPOSITION CONTAINING THE SAME | YAMANOUCHI PHARMA CO LTD (JP) | 2001-05-16 | — | — | EP | disclosed |
| US-6083955-A | HAVING A HIGH AFFINITY FOR DRUGS, ESPECIALLY ENDOSERINE RECEPTORS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-07-04 | — | — | US | disclosed |
| EP-0882719-A1 | ARYLETHENESULFONAMIDE DERIVATIVES AND DRUG COMPOSITION CONTAINING THE SAME | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-12-09 | — | — | EP | disclosed |