Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
| ▸ | F2RL1 | P55085 | 12/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7026082 | 0.87 | CASP6 (0.38) | CASP6F2RL1 | |
| SCHEMBL4972450 | 0.87 | GSK3B (0.44) | NISCHGSK3BNPC1RAB9ACCNB2 | |
| SCHEMBL4974089 | 0.85 | MC4R (0.40) | NISCHGSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL7024613 | 0.83 | CSNK1A1 (0.40) | NISCHNPC1RAB9A | |
| SCHEMBL7020750 | 0.82 | TRPA1 (0.38) | CASP6F2RL1 | |
| SCHEMBL1688524 | 0.82 | NISCH (0.49) | NISCHCASP6NPC1RAB9AF2RL1 | |
| SCHEMBL27747954 | 0.81 | CYP17A1 (0.42) | NISCHCASP6GSK3BNPC1RAB9A | |
| SCHEMBL27538105 | 0.79 | GSK3B (0.42) | NISCHCASP6GSK3BNPC1RAB9A | |
| SCHEMBL7852651 | 0.77 | HSP90AB1 (0.39) | NISCHGSK3BNPC1RAB9ACCNB2 | |
| SCHEMBL7026204 | 0.76 | NISCH (0.38) | NISCHGSK3BNPC1RAB9AGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100506801-C | Inhibitors of glycogen synthase kinase 3 | CHIRON CORP (US) | 2009-07-01 | — | — | CN | disclosed |
| CN-1592743-A | Inhibitors of glycogen synthase kinase 3 | CHIRON CORP (US) | 2005-03-09 | — | — | CN | disclosed |
| CN-1312807-A | Inhibitors of glycogen synthase kinase 3 | CHIRON CORP (US) | 2001-09-12 | — | — | CN | disclosed |
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |