Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840083 | 0.95 | GSK3B (0.50) | GSK3BPOLBTP53MEN1ALDH1A1 | |
| SCHEMBL7840554 | 0.93 | GSK3B (0.46) | GSK3BDRD2ADRA1ADRD3HTR7 | |
| SCHEMBL7844493 | 0.86 | DRD2 (0.52) | GSK3BDRD2ADRA1ADRD3HTR7 | |
| Hydrochloric Acid SCHEMBL8041535 | 0.85 | DRD2 (0.51) | GSK3BDRD2ADRA1ADRD3HTR7 | |
| SCHEMBL7841533 | 0.83 | GSK3B (0.43) | GSK3BPOLBTP53MEN1ALDH1A1 | |
| SCHEMBL7838517 | 0.81 | DRD2 (0.57) | GSK3BMEN1KMT2ADRD2ADRA1A | |
| SCHEMBL7829445 | 0.81 | DRD2 (0.55) | GSK3BDRD2ADRA1ADRD3HTR7 | |
| Hydrochloric Acid SCHEMBL8039750 | 0.81 | DRD2 (0.54) | GSK3BDRD2ADRA1ADRD3HTR7 | |
| SCHEMBL7838166 | 0.78 | DRD2 (0.49) | GSK3BTP53ALDH1A1DRD2ADRA1A | |
| SCHEMBL7839766 | 0.76 | ADRA1B (0.54) | DRD2ADRA1ADRD3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839144-B1 | PIPERAZINE DERIVATIVES AS THERAPEUTIC AGENTS | KNOLL GMBH (DE) | 2001-09-19 | — | — | EP | claimed |
| EP-0839144-A1 | PIPERAZINE DERIVATIVES AS THERAPEUTIC AGENTS | Knoll AG (DE) | 1998-05-06 | — | — | EP | claimed |
| WO-1997003067-A1 | PIPERAZINE DERIVATIVES AS THERAPEUTIC AGENTS | KNOLL AKTIENGESELLSCHAFT (DE) | 1997-01-30 | — | — | WO | claimed |
| US-6114334-A | CENTRAL NERVOUS SYSTEM DISORDERS | KNOLL AKTIENGESELLSCHAFT (DE) | 2000-09-05 | — | — | US | disclosed |