Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 3/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | MMP7 | P09237 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20988329 | 0.78 | CA2 (0.57) | FFAR1FFAR4ALDH1A1MEN1KMT2A | |
| SCHEMBL2228232 | 0.77 | SMN1; SMN2 (0.58) | ALDH1A1PKMMMP1MMP2MMP9 | |
| SCHEMBL30887502 | 0.77 | CA2 (0.60) | ALDH1A1MMP1MMP2MMP9MMP13 | |
| SCHEMBL1727771 | 0.76 | SLC1A3 (0.50) | ALDH1A1MEN1KMT2APKMMMP1 | |
| SCHEMBL2216960 | 0.76 | SLC1A3 (0.50) | ALDH1A1MEN1KMT2APKMMMP1 | |
| SCHEMBL7373802 | 0.76 | MMP9 (0.57) | MMP1MMP2MMP9MMP13MMP3 | |
| SCHEMBL10482884 | 0.75 | CA2 (0.57) | ALDH1A1MMP1MMP2MMP9MMP13 | |
| SCHEMBL10482887 | 0.75 | CA2 (0.57) | ALDH1A1MMP1MMP2MMP9MMP13 | |
| SCHEMBL1287356 | 0.75 | CA1 (0.53) | FFAR1FFAR4ALDH1A1MEN1KMT2A | |
| SCHEMBL12508301 | 0.74 | ALOX5AP (0.46) | ALDH1A1MMP1MMP2MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | disclosed |