Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 8/20 | 0.35 |
| ▸ | BMP1 | P13497 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848884 | 0.90 | CNR2 (0.35) | L3MBTL1CNR2BMP1 | |
| SCHEMBL7837398 | 0.88 | ALDH1A1 (0.36) | TDP1CXCR3ALDH1A1MEN1KMT2A | |
| SCHEMBL7846527 | 0.87 | CNR2 (0.46) | L3MBTL1CNR2CNR1TAS2R14BMP1 | |
| SCHEMBL7845581 | 0.83 | ALDH1A1 (0.34) | L3MBTL1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL7845849 | 0.79 | MAPK1 (0.32) | MAPK1 | |
| SCHEMBL7846766 | 0.74 | CNR2 (0.40) | CNR2CNR1TAS2R14BMP1TDP1 | |
| SCHEMBL7837576 | 0.73 | TBXA2R (0.32) | L3MBTL1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7838193 | 0.73 | ALDH1A1 (0.41) | CNR2CNR1TDP1CXCR3ALDH1A1 | |
| SCHEMBL7846525 | 0.72 | CNR2 (0.40) | CNR2CNR1TAS2R14PTGESTAS2R8 | |
| SCHEMBL7845257 | 0.71 | CNR1 (0.37) | CNR2CNR1TAS2R14PTGESTAS2R8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | disclosed |