Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | USP7 | Q93009 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841669 | 1.00 | MAOB (0.52) | MAOBROCK2PTGS2PTGS1NTRK1 | |
| SCHEMBL7843488 | 0.92 | PTGS2 (0.49) | MAOBPTGS2PTGS1CA1CA2 | |
| SCHEMBL7843885 | 0.92 | PTGS2 (0.53) | MAOBPTGS2PTGS1CA1CA2 | |
| SCHEMBL7844142 | 0.92 | PTGS2 (0.53) | MAOBPTGS2PTGS1CA1CA2 | |
| SCHEMBL7846026 | 0.92 | PTGS2 (0.49) | MAOBPTGS2PTGS1CA1CA2 | |
| SCHEMBL7846341 | 0.91 | CA2 (0.53) | PTGS2PTGS1CA1CA2CA12 | |
| SCHEMBL7842539 | 0.91 | PTGS2 (0.49) | MAOBPTGS2PTGS1CA1CA2 | |
| SCHEMBL7846343 | 0.91 | PTGS2 (0.49) | MAOBPTGS2PTGS1CA1CA2 | |
| SCHEMBL7839826 | 0.91 | CA2 (0.53) | PTGS2PTGS1CA1CA2CA12 | |
| SCHEMBL7843450 | 0.90 | PTGS2 (0.59) | MAOBROCK2PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |