Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3421020 | 0.87 | BRD4 (0.48) | BRD4MEN1KMT2AHPGDKDM4E | |
| SCHEMBL7836822 | 0.75 | CDK7 (0.44) | BRD4MEN1KMT2A | |
| SCHEMBL7847402 | 0.72 | MEN1 (0.49) | BRD4MEN1KMT2AHPGDKDM4E | |
| SCHEMBL7487239 | 0.72 | MAPT (0.46) | BRD4MEN1KMT2AHPGDKDM4E | |
| SCHEMBL8391492 | 0.71 | SMN1; SMN2 (0.46) | BRD4MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL7835034 | 0.70 | PRKAB2 (0.40) | — | |
| SCHEMBL7835484 | 0.69 | CDK2 (0.40) | — | |
| SCHEMBL7832150 | 0.69 | KDM4E (0.35) | MEN1KMT2AKDM4ESMN1; SMN2POLB | |
| SCHEMBL7847494 | 0.68 | CCNT1 (0.40) | BRD4KDM4EMAPK10GAASMN1; SMN2 | |
| SCHEMBL7551103 | 0.68 | MAPT (0.46) | BRD4MEN1KMT2AHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| US-5707997-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0714898-A1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-05 | — | — | EP | disclosed |