Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNH | P51946 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3421020 | 0.87 | BRD4 (0.48) | CDK7CDK9CCNT1CCNHBRD4 | |
| SCHEMBL7845276 | 0.75 | BRD4 (0.48) | BRD4MEN1KMT2A | |
| SCHEMBL7844914 | 0.75 | CDK7 (0.46) | CDK7CDK9CCNT1CCNHCDK2 | |
| SCHEMBL7846954 | 0.72 | CDK9 (0.63) | CDK7CDK9CCNT1CCNHPDE10A | |
| SCHEMBL8608009 | 0.72 | KCNN3 (0.59) | CDK7CDK9CCNT1CCNHPDE10A | |
| SCHEMBL7847494 | 0.72 | CCNT1 (0.40) | CDK7CDK9CCNT1CCNHCRHR1 | |
| SCHEMBL7847402 | 0.72 | MEN1 (0.49) | BRD4MEN1KMT2A | |
| SCHEMBL7846049 | 0.71 | CCNT1 (0.39) | CDK7CDK9CCNT1CCNHCRHR1 | |
| SCHEMBL7843197 | 0.71 | CDK9 (0.61) | CDK7CDK9CCNT1CCNHPDE10A | |
| SCHEMBL8391492 | 0.71 | SMN1; SMN2 (0.46) | BRD4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | claimed |