Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 9/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.40 |
| ▸ | POLB | P06746 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17569636 | 0.86 | MAPT (0.54) | MAPTSMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL6701858 | 0.86 | MAPT (0.54) | MAPTSMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL19275515 | 0.86 | MAPT (0.54) | MAPTSMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL7846551 | 0.86 | CNR1 (0.52) | MAPTSMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL7843005 | 0.84 | CYP17A1 (0.41) | MAPTMEN1KMT2APOLBCYP17A1 | |
| SCHEMBL7847281 | 0.83 | KMT2A (0.41) | MAPTSMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL7229054 | 0.82 | MAPT (0.47) | MAPTSMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL7841770 | 0.82 | TRPV1 (0.46) | MAPTSMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL7841418 | 0.76 | CYP17A1 (0.42) | MAPTRAB9ANPC1CYP17A1 | |
| SCHEMBL24341742 | 0.75 | RAB9A (0.48) | SMN1; SMN2RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157022-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000049015-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-24 | — | — | WO | disclosed |