SCHEMBL7845476

SCHEMBL7845476

O=C(N[C@@H](Cc1ccccc1)C(=O)N1CCCC1C(O)C(=O)NC1CCCCC1)c1cccs1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.50
RAB9A P51151 3/20 0.48
HPGD P15428 2/20 0.48
MEN1 O00255 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
TSHR P16473 1/20 0.48
CYP2C19 P33261 1/20 0.48
KMT2A Q03164 1/20 0.48
NPC1 O15118 1/20 0.48
KDM4E B2RXH2 1/20 0.47
CTSL P07711 1/20 0.47
GAA P10253 1/20 0.45
HSPA1A P0DMV8 1/20 0.45
HSPA5 P11021 1/20 0.45
HSPA9 P38646 1/20 0.45
HSPA2 P54652 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
CTSS P25774 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7851592 0.88 ALDH1A1 (0.54) ALDH1A1KDM4EACE2
SCHEMBL7855242 0.86 KDM4E (0.63) ALDH1A1RAB9AMEN1TSHRKMT2A
SCHEMBL7844779 0.84 HPGD (0.48) ALDH1A1RAB9AHPGDMEN1CYP1A2
SCHEMBL7853586 0.83 ALDH1A1 (0.49) ALDH1A1MEN1CYP3A4CYP2D6CYP2C19
SCHEMBL7855475 0.83 ACE (0.54) ALDH1A1KDM4ECTSLCTSS
SCHEMBL7852961 0.82 HTRA1 (0.50) ALDH1A1KDM4EACKR3ACE2
SCHEMBL7852935 0.82 ALDH1A1 (0.48) ALDH1A1KDM4ETDP1ACE2L3MBTL1
Hydrochloric Acid SCHEMBL7851195 0.82 ACE (0.53) ALDH1A1KDM4ECTSLCTSS
SCHEMBL7852525 0.82 KDM4E (0.49) ALDH1A1KDM4ETDP1L3MBTL1
SCHEMBL7843703 0.82 DPP4 (0.56) ALDH1A1CYP3A4CYP2D6CYP2C19KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0709373-B1 PYRROLIDINE DERIVATIVE ZAIDAN HOJIN BISEIBUTSU (JP) 2001-10-17 EP disclosed
US-5965556-A KETO-ACID AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS FOR INHIBITING THE ACTIVITY OF SERINE PROTEASE OR THIOL PROTEASE BY ADMINISTERING THE DERIVATIVE TO A MAMMAL; ALZHEIMER'S DISEASE ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) 1999-10-12 US disclosed
US-5756763-A ENZYME INHIBITOR ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) 1998-05-26 US disclosed
EP-0709373-A1 NOVEL PYRROLIDINE DERIVATIVE ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) 1996-05-01 EP disclosed