Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.54 |
| ▸ | REN | P00797 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 7/20 | 0.47 |
| ▸ | CTSS | P25774 | 5/20 | 0.47 |
| ▸ | CTSL | P07711 | 3/20 | 0.47 |
| ▸ | PREP | P48147 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7851195 | 0.99 | ACE (0.53) | ACERENEPHX1ALDH1A1KDM4E | |
| SCHEMBL7854074 | 0.88 | ACE (0.55) | ACEALDH1A1KDM4ECTSKCTSS | |
| SCHEMBL7852898 | 0.88 | ACE (0.55) | ACEALDH1A1KDM4ECTSKCTSS | |
| SCHEMBL7851530 | 0.88 | ACE (0.55) | ACEALDH1A1KDM4ECTSKCTSS | |
| SCHEMBL7851592 | 0.87 | ALDH1A1 (0.54) | ACEALDH1A1KDM4E | |
| SCHEMBL7855242 | 0.87 | KDM4E (0.63) | ACEALDH1A1KDM4E | |
| SCHEMBL7845173 | 0.86 | ACE (0.56) | ACEKDM4ECTSKCTSSCTSL | |
| SCHEMBL7856547 | 0.86 | CAPN1 (0.52) | EPHX1ALDH1A1CTSKCTSSCTSL | |
| SCHEMBL7853918 | 0.84 | CTSL (0.48) | ALDH1A1KDM4ECTSL | |
| SCHEMBL7852896 | 0.84 | ACE (0.56) | ACECTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709373-B1 | PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU (JP) | 2001-10-17 | — | — | EP | disclosed |
| US-5965556-A | KETO-ACID AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS FOR INHIBITING THE ACTIVITY OF SERINE PROTEASE OR THIOL PROTEASE BY ADMINISTERING THE DERIVATIVE TO A MAMMAL; ALZHEIMER'S DISEASE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1999-10-12 | — | — | US | disclosed |
| US-5756763-A | ENZYME INHIBITOR | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1998-05-26 | — | — | US | disclosed |
| EP-0709373-A1 | NOVEL PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1996-05-01 | — | — | EP | disclosed |