Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.46 |
| ▸ | F10 | P00742 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | FPR1 | P21462 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846162 | 0.95 | PTGS2 (0.46) | PTGS2F10MAPTMEN1CYP1A2 | |
| SCHEMBL7842757 | 0.92 | PTGS2 (0.46) | PTGS2F10MAPTAPAF1MAPK1 | |
| SCHEMBL7842019 | 0.92 | ATR (0.46) | PTGS2MAPTMEN1CYP1A2CYP2C19 | |
| SCHEMBL7844350 | 0.91 | PTGS2 (0.45) | PTGS2F10MEN1KMT2AALOX5 | |
| SCHEMBL7833108 | 0.91 | MAPT (0.46) | PTGS2F10MAPTMEN1KMT2A | |
| SCHEMBL7841887 | 0.90 | PTGS2 (0.43) | PTGS2F10MAPTMEN1KMT2A | |
| SCHEMBL7842580 | 0.90 | PTGS2 (0.43) | PTGS2F10MAPTMEN1KMT2A | |
| SCHEMBL7844026 | 0.88 | NPSR1 (0.45) | PTGS2F10MAPTALOX5 | |
| SCHEMBL7841016 | 0.87 | PTGS2 (0.46) | PTGS2MAPTMEN1KMT2AALOX5 | |
| SCHEMBL7841026 | 0.86 | ESRRG (0.48) | PTGS2MAPTMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |