Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842353 | 0.97 | NPC1 (0.48) | PTGS2NPC1RAB9AMAPTTP53 | |
| SCHEMBL7841896 | 0.96 | MAPT (0.46) | PTGS2NPC1RAB9AMAPTTP53 | |
| SCHEMBL7842757 | 0.95 | PTGS2 (0.46) | PTGS2NPC1RAB9AMAPTKMT2A | |
| SCHEMBL7845840 | 0.93 | NPSR1 (0.45) | PTGS2NPC1RAB9AMAPTTP53 | |
| SCHEMBL7846162 | 0.92 | PTGS2 (0.46) | PTGS2NPC1RAB9AMAPTTP53 | |
| SCHEMBL7842512 | 0.91 | ESRRG (0.48) | PTGS2NPC1RAB9AMAPTTP53 | |
| SCHEMBL7832325 | 0.90 | PTGS2 (0.45) | PTGS2MAPTTP53ALOX5KMT2A | |
| SCHEMBL7845585 | 0.89 | GRM5 (0.43) | PTGS2NPC1RAB9AMAPTATR | |
| SCHEMBL7844202 | 0.89 | L3MBTL1 (0.44) | PTGS2NPC1RAB9AMAPTKMT2A | |
| SCHEMBL7842019 | 0.88 | ATR (0.46) | PTGS2NPC1RAB9AMAPTATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |