Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 19/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ESRRG | P62508 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844024 | 1.00 | PTGS2 (0.62) | PTGS2PTGS1ESR1ESRRG | |
| SCHEMBL7841011 | 0.92 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL7846158 | 0.92 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL7844347 | 0.91 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL7832323 | 0.91 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL7841022 | 0.91 | ESR1 (0.61) | PTGS2PTGS1ESR1ESRRG | |
| SCHEMBL7842507 | 0.91 | ESR1 (0.61) | PTGS2PTGS1ESR1ESRRG | |
| SCHEMBL7842350 | 0.89 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL7842017 | 0.89 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL7843989 | 0.89 | PTGS2 (0.50) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |