Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PRKAB2 | O43741 | 6/20 | 0.51 |
| ▸ | PRKAG1 | P54619 | 6/20 | 0.51 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.51 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.51 |
| ▸ | PRKAG3 | Q9UGI9 | 6/20 | 0.51 |
| ▸ | PRKAG2 | Q9UGJ0 | 6/20 | 0.51 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.51 |
| ▸ | HAT1 | O14929 | 3/20 | 0.50 |
| ▸ | EP300 | Q09472 | 3/20 | 0.50 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | BAD | Q92934 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30417250 | 0.86 | KDM4E (0.66) | KDM4EPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL2818109 | 0.86 | KDM4E (0.66) | KDM4EPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL7494290 | 0.85 | MAPT (0.57) | HAT1EP300GPR17MEN1KMT2A | |
| SCHEMBL7847121 | 0.84 | CDK4 (0.46) | HAT1EP300HPGDCYP1A2KMT2A | |
| SCHEMBL31147988 | 0.84 | NR4A2 (0.63) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL6325476 | 0.82 | NR4A2 (0.47) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL27839464 | 0.81 | NR4A2 (0.46) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL10835850 | 0.78 | ALDH1A1 (0.59) | KDM4EPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4452877 | 0.77 | KDM4E (0.77) | KDM4EHPGDMEN1ALDH1A1CYP1A2 | |
| SCHEMBL30416773 | 0.77 | KDM4E (0.77) | KDM4EHPGDMEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821685-B1 | INDOLE-3-CARBONYL AND INDOLE-3-SULFONYL DERIVATIVES AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LAB (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-0821685-A1 | INDOLE-3-CARBONYL AND INDOLE-3-SULFONYL DERIVATIVES AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1998-02-04 | — | — | EP | disclosed |
| US-5654305-A | TREATING PLATELET ACTIVATING FACTOR MEDIATED DISORDERS | ABBOTT LABORATORIES (US) | 1997-08-05 | — | — | US | disclosed |
| WO-1996033196-A1 | INDOLE-3-CARBONYL AND INDOLE-3-SULFONYL DERIVATIVES AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-10-24 | — | — | WO | disclosed |
| US-5567711-A | Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists | ABBOTT LABORATORIES (US) | 1996-10-22 | — | — | US | disclosed |