Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 9/20 | 0.55 |
| ▸ | CA2 | P00918 | 9/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.53 |
| ▸ | CA12 | O43570 | 3/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842502 | 1.00 | CA1 (0.55) | CA1CA2PTGS2CA12CA9 | |
| SCHEMBL7845738 | 0.95 | CA1 (0.54) | CA1CA2PTGS2CA12CA9 | |
| SCHEMBL7832892 | 0.95 | CA1 (0.54) | CA1CA2PTGS2CA12CA9 | |
| SCHEMBL7844099 | 0.90 | PTGS2 (0.52) | CA1CA2PTGS2CA12CA9 | |
| SCHEMBL7845271 | 0.90 | PTGS2 (0.53) | CA1CA2PTGS2CA12CA9 | |
| SCHEMBL7839688 | 0.90 | PTGS2 (0.53) | CA1CA2PTGS2CA12CA9 | |
| SCHEMBL7843757 | 0.90 | PTGS2 (0.62) | PTGS2PTGS1POLB | |
| SCHEMBL7846006 | 0.90 | PTGS2 (0.52) | CA1CA2PTGS2CA12CA9 | |
| SCHEMBL7844958 | 0.90 | PTGS2 (0.62) | PTGS2PTGS1POLB | |
| SCHEMBL7846341 | 0.90 | CA2 (0.53) | CA1CA2PTGS2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |