Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.52 |
| ▸ | NAMPT | P43490 | 3/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17199017 | 0.85 | KDM4E (0.80) | KDM4EPOLBSMN1; SMN2MAPTMEN1 | |
| SCHEMBL17186325 | 0.83 | KDM4E (0.60) | KDM4EPOLBSMN1; SMN2MAPTNAMPT | |
| SCHEMBL3510455 | 0.82 | KDM4E (0.79) | KDM4EPOLBSMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL17186457 | 0.82 | KDM4E (0.59) | KDM4EPOLBSMN1; SMN2MAPTNAMPT | |
| Hydrochloric Acid SCHEMBL18605769 | 0.81 | KDM4E (0.77) | KDM4EPOLBSMN1; SMN2MAPT | |
| SCHEMBL6279160 | 0.76 | CDK2 (0.53) | SMN1; SMN2HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL3430425 | 0.74 | SMN1; SMN2 (0.77) | SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL3656623 | 0.73 | ROCK2 (0.62) | KDM4ESMN1; SMN2MAPTNAMPTMEN1 | |
| Hydrochloric Acid SCHEMBL17186179 | 0.73 | SMN1; SMN2 (0.74) | KDM4ESMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL17186221 | 0.70 | SMN1; SMN2 (0.61) | KDM4EPOLBSMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124811-A1 | 2-UREIDO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026203-A1 | 2-UREIDO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-05-11 | — | — | WO | disclosed |