SCHEMBL7846333

SCHEMBL7846333

CS(=O)(=O)c1ccc(-c2nc(C(=O)NCc3ccccc3)sc2-c2ccc(F)cc2)cc1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 20/20 0.66
PTGS1 P23219 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7841076 1.00 PTGS2 (0.66) PTGS2PTGS1
SCHEMBL7842466 0.95 PTGS2 (0.66) PTGS2PTGS1
SCHEMBL7846156 0.95 PTGS2 (0.66) PTGS2PTGS1
SCHEMBL7843450 0.91 PTGS2 (0.59) PTGS2PTGS1
SCHEMBL7842482 0.91 PTGS2 (0.59) PTGS2PTGS1
SCHEMBL7832885 0.91 PTGS2 (0.64) PTGS2PTGS1
SCHEMBL7846997 0.91 PTGS2 (0.64) PTGS2PTGS1
SCHEMBL7844958 0.90 PTGS2 (0.62) PTGS2PTGS1
SCHEMBL7840235 0.90 PTGS2 (0.66) PTGS2PTGS1
SCHEMBL7841879 0.90 PTGS2 (0.66) PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1125932-A2 Substituted thiazoles for the treatment of inflammation G.D. SEARLE & CO. (US) 2001-08-22 EP disclosed
US-5668161-A Substituted thiazoles for the treatment of inflammation G.D. SEARLE & CO. (US) 1997-09-16 US disclosed