Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | CCR4 | P51679 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | MC3R | P41968 | 1/20 | 0.40 |
| ▸ | MC1R | Q01726 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | ECE1 | P42892 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946762 | 1.00 | MMP9 (0.52) | MMP9BDKRB2AKR1C3AKR1C1CCR4 | |
| SCHEMBL6951034 | 0.90 | MMP9 (0.53) | MMP9BDKRB2AKR1C3AKR1C1CCR4 | |
| SCHEMBL6945270 | 0.90 | MMP9 (0.53) | MMP9BDKRB2AKR1C3AKR1C1CCR4 | |
| SCHEMBL6949077 | 0.87 | MMP9 (0.50) | MMP9BDKRB2AKR1C3AKR1C1CCR4 | |
| SCHEMBL7844033 | 0.87 | MMP9 (0.50) | MMP9BDKRB2AKR1C3AKR1C1CCR4 | |
| SCHEMBL5404212 | 0.82 | LMNA (0.44) | AKR1C3AKR1C1CCR4ALDH1A1LMNA | |
| SCHEMBL5404204 | 0.82 | LMNA (0.44) | AKR1C3AKR1C1CCR4ALDH1A1LMNA | |
| SCHEMBL5406593 | 0.79 | AKR1C3 (0.43) | MMP9AKR1C3AKR1C1CCR4ALDH1A1 | |
| SCHEMBL6818867 | 0.78 | ECE1 (0.52) | AKR1C3AKR1C1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5421626 | 0.78 | LMNA (0.41) | AKR1C3AKR1C1ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877737-B1 | NOVEL N-(ARYLSULPHONYL)AMINO ACID DERIVATIVES HAVING BRADYKININ RECEPTOR AFFINITY | SANOFI SYNTHELABO (FR) | 2001-08-01 | — | — | EP | disclosed |
| EP-0877737-A1 | NOVEL N-(ARYLSULPHONYL)AMINO ACID DERIVATIVES HAVING BRADYKININ RECEPTOR AFFINITY | SANOFI (FR) | 1998-11-18 | — | — | EP | disclosed |
| WO-1997025315-A1 | NOVEL N-(ARYLSULPHONYL)AMINO ACID DERIVATIVES HAVING BRADYKININ RECEPTOR AFFINITY | SANOFI (FR) | 1997-07-17 | — | — | WO | disclosed |