Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846615 | 0.85 | PTGS2 (0.55) | PTGS2PTGS1MEN1NPC1ALDH1A1 | |
| SCHEMBL7841925 | 0.83 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL7841911 | 0.79 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL7840385 | 0.76 | PTGS2 (0.72) | PTGS2PTGS1 | |
| SCHEMBL7844794 | 0.74 | PTGS2 (0.57) | PTGS2PTGS1MEN1NPC1ALDH1A1 | |
| SCHEMBL7841923 | 0.72 | PTGS2 (0.78) | PTGS2PTGS1 | |
| SCHEMBL13367649 | 0.72 | ALDH1A1 (0.74) | MEN1NPC1ALDH1A1RAB9AKMT2A | |
| SCHEMBL7833314 | 0.72 | PTGS2 (0.59) | PTGS2PTGS1ALDH1A1 | |
| SCHEMBL7840379 | 0.70 | PTGS2 (0.84) | PTGS2PTGS1 | |
| SCHEMBL5698728 | 0.69 | PTGS2 (0.74) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |