Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.60 |
| ▸ | SETD2 | Q9BYW2 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.54 |
| ▸ | SMO | Q99835 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2970434 | 0.91 | MAPK14 (0.64) | MAPK14SETD2LCKCSF1RKDR | |
| SCHEMBL7856635 | 0.87 | MAPK14 (0.57) | MAPK14SETD2LCKCSF1RKDR | |
| SCHEMBL7805605 | 0.86 | MAPK14 (0.61) | MAPK14SETD2SMO | |
| SCHEMBL14078239 | 0.84 | MAPK14 (0.65) | MAPK14SETD2LCKCSF1RKDR | |
| SCHEMBL7846077 | 0.84 | MAPK14 (0.73) | MAPK14SMORAF1BRAF | |
| SCHEMBL6484389 | 0.84 | MAPK14 (0.70) | MAPK14SETD2CSF1RSMORAF1 | |
| SCHEMBL7804583 | 0.83 | MAPK14 (0.62) | MAPK14SETD2SMORAF1BRAF | |
| SCHEMBL7846789 | 0.83 | MAPK14 (0.55) | MAPK14 | |
| SCHEMBL27528929 | 0.83 | MAPK14 (0.59) | MAPK14SETD2LCKCSF1RKDR | |
| SCHEMBL7838506 | 0.82 | MAPK14 (0.70) | MAPK14RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102743-A1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007980-A1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-02-17 | — | — | WO | disclosed |