SCHEMBL7846854

SCHEMBL7846854

CCCCCN(CCCCC)C(=S)Cl

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CA12 O43570 6/20 0.58
CA1 P00915 6/20 0.58
CA9 Q16790 6/20 0.58
CA2 P00918 4/20 0.58
MGLL Q99685 1/20 0.52
ALDH1A1 P00352 3/20 0.48
ALDH2 P05091 1/20 0.48
DNM1 Q05193 3/20 0.40
TSHR P16473 2/20 0.36
MMP1 P03956 1/20 0.35
MMP2 P08253 1/20 0.35
MMP3 P08254 1/20 0.35
MMP8 P22894 1/20 0.35
GBA1 P04062 1/20 0.34
ZDHHC20 Q5W0Z9 1/20 0.34
ZDHHC2 Q9UIJ5 1/20 0.34
THRB P10828 1/20 0.33
TP53 P04637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11756133 0.98 CA12 (0.61) CA12CA1CA9CA2MGLL
SCHEMBL9348588 0.92 ALDH1A1 (0.56) CA12CA1CA9CA2MGLL
SCHEMBL10937983 0.81 CA12 (0.57) CA12CA1CA9CA2MGLL
SCHEMBL28705278 0.79 CA12 (0.62) CA12CA1CA9CA2MGLL
SCHEMBL8365223 0.77 CA12 (0.91) CA12CA1CA9CA2MGLL
SCHEMBL7262845 0.77 CA12 (0.67) CA12CA1CA9CA2MGLL
SCHEMBL8164965 0.77 CA12 (0.60) CA12CA1CA9CA2MGLL
SCHEMBL11243050 0.77 CA12 (0.67) CA12CA1CA9CA2MGLL
SCHEMBL701003 0.75 CA12 (0.95) CA12CA1CA9CA2MGLL
SCHEMBL7522177 0.75 CA12 (0.86) CA12CA1CA9CA2MGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0842178-B1 FUROPYRIDINE, THIENOPYRIDINE, PYRROLOPYRIDINE AND RELATED PYRIMIDINE, PYRIDAZINE AND TRIAZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2001-03-28 EP disclosed
EP-0973777-A1 FUROPYRIDINE, THIENOPYRIDINE, PYRROLOPYRIDINE AND RELATED PYRIMIDINE, PYRIDAZINE AND TRIAZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 2000-01-26 EP disclosed
US-6001849-A Furopyridine, thienopyridine pyrrolopyridine useful in controlling chemical synaptic transmission ABBOTT LABORATORIES (US) 1999-12-14 US disclosed
WO-1998046609-A1 FUROPYRIDINE, THIENOPYRIDINE, PYRROLOPYRIDINE AND RELATED PYRIMIDINE, PYRIDAZINE AND TRIAZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1998-10-22 WO disclosed
EP-0842178-A1 FUROPYRIDINE, THIENOPYRIDINE, PYRROLOPYRIDINE AND RELATED PYRIMIDINE, PYRIDAZINE AND TRIAZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 1998-05-20 EP disclosed
WO-1997005139-A1 FUROPYRIDINE, THIENOPYRIDINE, PYRROLOPYRIDINE AND RELATED PYRIMIDINE, PYRIDAZINE AND TRIAZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1997-02-13 WO disclosed