Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 13/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839882 | 0.85 | KMT2A (0.46) | PTGS2ALOX5PTGDR2 | |
| SCHEMBL7844350 | 0.83 | PTGS2 (0.45) | APEX1PTGS2ALOX5PTGS1 | |
| SCHEMBL7833915 | 0.83 | PTGS2 (0.62) | APEX1PTGS2PTGS1 | |
| SCHEMBL7840342 | 0.83 | PTGS2 (0.48) | PTGS2ALOX5PTGS1 | |
| SCHEMBL7845249 | 0.83 | PTGS2 (0.50) | PTGS2ALOX5PTGS1 | |
| SCHEMBL7832496 | 0.82 | KMT2A (0.51) | PTGS2ALOX5PTGDR2 | |
| SCHEMBL7846460 | 0.82 | PTGDR2 (0.57) | PTGS2ALOX5PTGDR2 | |
| SCHEMBL7845455 | 0.82 | PTGDR2 (0.46) | PTGS2ALOX5PTGDR2 | |
| SCHEMBL7844602 | 0.82 | PTGS2 (0.47) | PTGS2ALOX5PTGS1 | |
| SCHEMBL7842558 | 0.80 | PTGS2 (0.48) | PTGS2ALOX5PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |