Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832496 | 0.86 | KMT2A (0.51) | PTGDR2PTGS2ALOX5MAPTMEN1 | |
| SCHEMBL7846456 | 0.86 | PTGDR2 (0.59) | PTGDR2PTGS2 | |
| SCHEMBL7846877 | 0.82 | APEX1 (0.55) | PTGDR2PTGS2ALOX5 | |
| SCHEMBL7842533 | 0.82 | PTGS2 (0.49) | PTGDR2PTGS2MAPTMEN1ALDH1A1 | |
| SCHEMBL7840342 | 0.81 | PTGS2 (0.48) | PTGS2ALOX5MAPTALDH1A1 | |
| SCHEMBL7843751 | 0.80 | PTGDR2 (0.59) | PTGDR2PTGS2MAPTMEN1KMT2A | |
| SCHEMBL7845455 | 0.80 | PTGDR2 (0.46) | PTGDR2PTGS2ALOX5MAPTMEN1 | |
| SCHEMBL7844602 | 0.80 | PTGS2 (0.47) | PTGS2ALOX5 | |
| SCHEMBL7842558 | 0.79 | PTGS2 (0.48) | PTGS2ALOX5 | |
| SCHEMBL7844008 | 0.78 | PTGS2 (0.54) | PTGDR2PTGS2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |