Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 14/20 | 0.63 |
| ▸ | CCNT1 | O60563 | 13/20 | 0.63 |
| ▸ | CDK7 | P50613 | 5/20 | 0.63 |
| ▸ | CCNH | P51946 | 4/20 | 0.63 |
| ▸ | CDK2 | P24941 | 4/20 | 0.53 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.53 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.53 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 3/20 | 0.41 |
| ▸ | CCND1 | P24385 | 3/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
| ▸ | CDK3 | Q00526 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843197 | 0.87 | CDK9 (0.61) | CDK9CCNT1CDK7CCNHCDK2 | |
| SCHEMBL7845174 | 0.81 | CDK7 (0.54) | CDK9CCNT1CDK7CCNHCDK2 | |
| SCHEMBL11606779 | 0.80 | CDK9 (0.52) | CDK9CCNT1CDK7CCNHCDK2 | |
| SCHEMBL7442948 | 0.78 | CDK9 (0.51) | CDK9CCNT1CDK7CCNHCDK2 | |
| SCHEMBL7003416 | 0.78 | PDE10A (0.54) | CDK9CCNT1CDK7CCNHCDK2 | |
| SCHEMBL21946118 | 0.78 | CDK9 (1.00) | CDK9CCNT1CDK7CCNHCDK2 | |
| SCHEMBL7847808 | 0.77 | CDK7 (0.50) | CDK9CCNT1CDK7CCNHCDK2 | |
| SCHEMBL8411610 | 0.76 | CDK9 (0.50) | CDK9CCNT1CDK7CCNHCDK2 | |
| SCHEMBL13288401 | 0.73 | PDE10A (0.51) | CDK9CCNT1CDK7CCNHCDK2 | |
| SCHEMBL13288422 | 0.73 | CDK7 (0.46) | CDK9CCNT1CDK7CCNHCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| US-5707997-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0714898-A1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-05 | — | — | EP | disclosed |