Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 2/20 | 0.54 |
| ▸ | CDK9 | P50750 | 2/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.54 |
| ▸ | CCNH | P51946 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847808 | 0.95 | CDK7 (0.50) | CDK7CDK9CCNT1CCNHCDK2 | |
| SCHEMBL7847802 | 0.91 | CDK9 (0.52) | CDK7CDK9CCNT1CCNHCDK2 | |
| SCHEMBL7846977 | 0.84 | PRKAB2 (0.48) | CDK7CDK9CCNT1CCNHCDK2 | |
| SCHEMBL11606779 | 0.83 | CDK9 (0.52) | CDK7CDK9CCNT1CCNHCDK2 | |
| SCHEMBL7442948 | 0.82 | CDK9 (0.51) | CDK7CDK9CCNT1CCNHCDK2 | |
| SCHEMBL7003416 | 0.82 | PDE10A (0.54) | CDK7CDK9CCNT1CCNHCDK2 | |
| SCHEMBL7846954 | 0.81 | CDK9 (0.63) | CDK7CDK9CCNT1CCNHCDK2 | |
| SCHEMBL7845502 | 0.81 | CDK2 (0.41) | CDK7CDK9CCNT1CCNHCDK2 | |
| SCHEMBL7843197 | 0.79 | CDK9 (0.61) | CDK7CDK9CCNT1CCNHCDK2 | |
| SCHEMBL7848321 | 0.78 | CDK2 (0.40) | CDK7CDK9CCNT1CCNHCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-11292879-A | — | — | None | — | — | JP | disclosed |
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| JP-H11292879-A | CARBOXAMIDE DERIVATIVE | OTSUKA PHARMACEUT FACTORY INC | 1999-10-26 | — | — | JP | disclosed |
| US-5707997-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0714898-A1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-05 | — | — | EP | disclosed |