Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 3/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488995 | 0.85 | EGFR (0.58) | EGFRHDAC1HDAC6HDAC5 | |
| SCHEMBL7689206 | 0.81 | EGFR (0.47) | EGFR | |
| SCHEMBL2637564 | 0.78 | EGFR (0.69) | EGFRHDAC1HDAC6HDAC5NCF1 | |
| SCHEMBL29831918 | 0.78 | EGFR (0.59) | EGFRNCF1 | |
| SCHEMBL4649110 | 0.75 | EGFR (0.70) | EGFRHDAC1HDAC6HDAC5NCF1 | |
| SCHEMBL30504578 | 0.75 | EGFR (0.70) | EGFRHDAC1HDAC6HDAC5NCF1 | |
| SCHEMBL30791005 | 0.75 | EGFR (0.52) | EGFR | |
| SCHEMBL18128963 | 0.75 | EGFR (0.52) | EGFR | |
| SCHEMBL13837704 | 0.74 | EGFR (0.73) | EGFRHDAC1HDAC6HDAC5 | |
| SCHEMBL7574519 | 0.74 | EGFR (0.55) | EGFRHDAC1HDAC6HDAC5HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157011-A1 | 4-AMINO- QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES | Boehringer Ingelheim Pharma KG (DE) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000051991-A1 | 4-AMINO-QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANsSDUCTION MEDIATED BY TYROSINE KINASES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-08 | — | — | WO | disclosed |