Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | BCHE | P06276 | 2/20 | 0.57 |
| ▸ | ACHE | P22303 | 2/20 | 0.57 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.54 |
| ▸ | CCND1 | P24385 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7855224 | 0.87 | MEN1 (0.66) | MEN1KMT2ANPSR1MAPTPOLB | |
| SCHEMBL7853851 | 0.87 | MAPT (0.66) | MEN1KMT2ANPSR1MAPTPOLB | |
| SCHEMBL7838803 | 0.86 | LMNA (0.76) | MEN1KMT2ANPSR1MAPTPOLB | |
| SCHEMBL7839075 | 0.86 | MEN1 (0.65) | MEN1KMT2ANPSR1MAPTPOLB | |
| SCHEMBL7844386 | 0.86 | KMT2A (0.65) | MEN1KMT2ANPSR1MAPTPOLB | |
| SCHEMBL7852539 | 0.86 | MEN1 (0.65) | MEN1KMT2ANPSR1MAPTPOLB | |
| SCHEMBL7854545 | 0.83 | MEN1 (0.61) | MEN1KMT2ANPSR1MAPTPOLB | |
| SCHEMBL7855977 | 0.82 | MEN1 (0.70) | MEN1KMT2ANPSR1MAPTPOLB | |
| SCHEMBL7853106 | 0.82 | MAPT (0.66) | MEN1KMT2ANPSR1MAPTPOLB | |
| SCHEMBL7856952 | 0.81 | KMT2A (0.68) | MEN1KMT2ANPSR1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140914-A1 | NON-PEPTIDE NK1 RECEPTORS ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037462-A1 | NON-PEPTIDE NK1 RECEPTORS ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2000-06-29 | — | — | WO | disclosed |