Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MYC | P01106 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | KDM6B | O15054 | 1/20 | 0.45 |
| ▸ | KDM6A | O15550 | 1/20 | 0.45 |
| ▸ | TET3 | O43151 | 1/20 | 0.45 |
| ▸ | KDM4A | O75164 | 1/20 | 0.45 |
| ▸ | KDM4B | O94953 | 1/20 | 0.45 |
| ▸ | KDM5C | P41229 | 1/20 | 0.45 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.45 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.45 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.45 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.45 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.45 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876755 | 0.86 | KDM4E (0.59) | KDM4ETDP1MYCL3MBTL1KDM4C | |
| SCHEMBL30555267 | 0.86 | KDM4E (0.59) | KDM4ETDP1MYCL3MBTL1KDM4C | |
| SCHEMBL31190966 | 0.84 | KDM4E (0.53) | KDM4ETDP1MYCL3MBTL1ALDH1A1 | |
| SCHEMBL8111830 | 0.81 | DHODH (0.53) | KDM4ETDP1MYCL3MBTL1KDM6B | |
| SCHEMBL15903248 | 0.81 | KDM4E (0.50) | KDM4ETDP1MYCL3MBTL1ALDH1A1 | |
| SCHEMBL725345 | 0.81 | KDM4E (0.50) | KDM4ETDP1MYCL3MBTL1ALDH1A1 | |
| SCHEMBL7032479 | 0.80 | KDM4E (0.78) | KDM4ETDP1MYCL3MBTL1ALDH1A1 | |
| SCHEMBL10000544 | 0.80 | KDM4E (0.65) | KDM4ETDP1MYCL3MBTL1KDM4C | |
| SCHEMBL8102349 | 0.77 | KDM4E (0.50) | KDM4ETDP1L3MBTL1KDM6BKDM6A | |
| SCHEMBL14936823 | 0.77 | KDM4E (0.61) | KDM4ETDP1L3MBTL1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1335850-A | Quinoline derivatives | SMITHKLINE BEECHMA PLC (GB) | 2002-02-13 | — | — | CN | disclosed |
| EP-1140946-A2 | QUINOLINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035919-A2 | QUINOLINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2000-06-22 | — | — | WO | disclosed |