Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | KDM4A | O75164 | 2/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.49 |
| ▸ | KDM6B | O15054 | 1/20 | 0.49 |
| ▸ | KDM6A | O15550 | 1/20 | 0.49 |
| ▸ | TET3 | O43151 | 1/20 | 0.49 |
| ▸ | KDM4B | O94953 | 1/20 | 0.49 |
| ▸ | KDM5C | P41229 | 1/20 | 0.49 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.49 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.49 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.49 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.49 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL465563 | 0.82 | KDM4E (0.55) | KDM4ETDP1L3MBTL1RAB9AKDM4C | |
| SCHEMBL30720582 | 0.82 | NR4A1 (0.64) | KDM4ENR4A1NR4A2NR4A3TDP1 | |
| SCHEMBL1324771 | 0.82 | NR4A1 (0.64) | KDM4ENR4A1NR4A2NR4A3TDP1 | |
| SCHEMBL28455317 | 0.81 | KDM4E (0.50) | KDM4ETDP1L3MBTL1ALDH1A1ALOX15 | |
| SCHEMBL435474 | 0.81 | HNF4A (0.59) | KDM4ETDP1L3MBTL1KDM4AEGLN1 | |
| SCHEMBL7751865 | 0.80 | NAPRT (0.55) | KDM4ETDP1L3MBTL1ALDH1A1ALOX15 | |
| SCHEMBL126694 | 0.80 | KDM4E (0.48) | KDM4ETDP1L3MBTL1KDM4CALDH1A1 | |
| SCHEMBL8111830 | 0.80 | DHODH (0.53) | KDM4ENR4A1NR4A2NR4A3TDP1 | |
| SCHEMBL27985 | 0.79 | NR4A1 (0.73) | KDM4ENR4A1NR4A2NR4A3L3MBTL1 | |
| SCHEMBL29406795 | 0.79 | NR4A1 (0.73) | KDM4ENR4A1NR4A2NR4A3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047691-A1 | QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999031086-A1 | QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-06-24 | — | — | WO | disclosed |