Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | REN | P00797 | 3/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 9/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CCND1 | P24385 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25154223 | 0.84 | HTR7 (0.56) | HTR7HTR2AHTR2CCDK4CCND1 | |
| SCHEMBL91358 | 0.81 | HTR2A (0.51) | HTR7RENMCL1HTR2AHTR2C | |
| SCHEMBL13962823 | 0.79 | MCL1 (0.46) | RENMCL1HTR2AHTR2CGLO1 | |
| SCHEMBL13962828 | 0.79 | MCL1 (0.46) | RENMCL1HTR2AHTR2CGLO1 | |
| SCHEMBL8265371 | 0.79 | MCL1 (0.46) | RENMCL1HTR2AHTR2CGLO1 | |
| SCHEMBL1049671 | 0.79 | HTR7 (0.51) | HTR7MCL1HTR2AHTR2CGLO1 | |
| SCHEMBL13131405 | 0.78 | HTR7 (0.52) | HTR7RENMCL1HTR2AHTR2C | |
| SCHEMBL20614497 | 0.77 | HTR1D (0.62) | HTR7HTR2AHTR2C | |
| SCHEMBL3995842 | 0.75 | CDK4 (0.70) | HTR2AHTR2CGLO1CDK4CCND1 | |
| SCHEMBL26674331 | 0.75 | HTR7 (0.53) | HTR7HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |