Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.37 |
| ▸ | HPGD | P15428 | 7/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8127546 | 0.85 | ALDH1A1 (0.38) | KDM4EALDH1A1HPGDMAPTRAB9A | |
| SCHEMBL7844280 | 0.79 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDMAPTRAB9A | |
| SCHEMBL7848006 | 0.78 | ALDH1A1 (0.37) | KDM4EALDH1A1HPGDMAPTRAB9A | |
| SCHEMBL1697927 | 0.75 | TRPM8 (0.48) | KDM4EALDH1A1HPGDMAPTRAB9A | |
| SCHEMBL1697915 | 0.70 | KDM4E (0.46) | KDM4EALDH1A1HPGDMAPTRAB9A | |
| SCHEMBL1697873 | 0.69 | KDM4E (0.54) | KDM4EALDH1A1HPGDMAPTRAB9A | |
| SCHEMBL8129486 | 0.68 | SMN1; SMN2 (0.34) | KDM4EALDH1A1HPGDMAPTRAB9A | |
| SCHEMBL14302410 | 0.66 | TP53 (0.42) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL8127548 | 0.65 | ALDH1A1 (0.38) | KDM4EALDH1A1HPGDMAPTRAB9A | |
| SCHEMBL1697901 | 0.64 | KDM4E (0.41) | KDM4EALDH1A1HPGDMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942911-B1 | BENZOPYRANOPYRROLE AND BENZOPYRANOPYRIDINE ALPHA-1 ADRENERGIC COMPOUNDS | ABBOTT LAB (US) | 2001-10-17 | — | — | EP | disclosed |
| US-6046207-A | FOR INHIBITING ALPHA-1 ADRENORECEPTORS AND TREATING BENIGN PROSTATIC HYPERPLASIA, ALSO CALLED BENIGN PROSTATIC HYPERTROPHY, OR OTHER UROLOGICAL OR GYNECOLOGICAL DISEASES SUCH AS BLADDER OUTLET OBSTRUCTION, NEUROGENIC BLADDER | ABBOTT LABORATORIES | 2000-04-04 | — | — | US | disclosed |